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 Frequently evaluate people using a heritage of seizure Ailments for worsened seizure Manage in the course of DEMEROL Tablets and Oral Answer therapy. Use of DEMEROL Tablets and Oral Option for an extended length of time may well raise the possibility of toxicity (e.g., seizures) with the accumulation in the meperidine metabolite, normeperidine

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5.four Challenges from Concomitant Use with Benzodiazepines or Other CNS Depressants Profound sedation, respiratory despair, coma, and Loss of life may well outcome within the concomitant use of DEMEROL Tablets or Oral Option with benzodiazepines and/or other CNS depressants, like Alcoholic beverages (e.g., non-benzodiazepine sedatives/hypnotics, a